Drawing a pistol from a holster while facing uprange is a disqualification. Learn how to safely perform a draw during a facing uprange start in this NROI Tips video.
This rule (10.5.16) not only applies to facing uprange starts, but also to any other time a holstered pistol is being drawn during a course of fire. The key to not earning a DQ while drawing a holstered pistol is to make sure the front of your holster, or the top of the slide of your pistol for race holsters, is not on the uprange side of the 180 line. Make sure everything is pointing downrange before you draw and it keeps the other competitors, ROs, and spectators safe.